Explain how the cell cycle is normally controlled, including reference to the role of tumor-suppressor genes:

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BraeBrae0 BraeBrae0

09-03-2018
Biology

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Explain how the cell cycle is normally controlled, including reference to the role of tumor-suppressor genes:

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Diatonic254 Diatonic254 · Answer 1 · 2018-03-19T15:43:29+01:00

The cell cycle is composed of S (synthetic) phase and M (Mitotic) phase. In between are G1 and G2 phases. cyclin-dependent kinases propel cell division. Their activation results in the progression of a cell from one phase to another while their inactivation arrests a cell in a phase. In case of damage to DNA during a cell cycle, transcription factors p53 (a renowned tumor suppressor) are recruited. P53 inhibits cyclins-dependent kinases and also induces cell apoptosis if DNA is not repaired.